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SER is service cable. You do not want to run that in conduit, especially for that distance. The size conduit required, and extra work involved, would offset any savings you might see.
If you go the circuit route, as opposed to a sub-panel, DEFINITELY go with a MWBC (multi-wire branch circuit or shared neutral circuit <10/3 cable>).
For one extra conductor you will get an extra circuit, which will in turn help lessen voltage drop when both are being used as I said earlier.
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No, that's not me in the avatar. I just like the picture. 
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