Please note the advice below is useful only if the wall tiles are not set into concrete but set onto wall board (hardi-backer or otherwise.) If the tile is set into concrete (with a metal mesh backing) it will be far more difficult to extracate the tiles you want to replace and I would suggest going with Jimmers suggestions.

You would be able to tell by looking into a plumbing access panel to see if there is metal mesh visible...
If the holes are in the tile, you can also replace those few tiles if you can find exact matches. I use a hammer and a small nail to clean out the grout around the tile and then (somewhat gently) chisel the tile out, mastik and replace with a new tile and then re-grout. It really is pretty easy.